Bioanalytical Chemistry Platform (animal, human)

Name of entity

Bioanalytical Chemistry Platform

Entity type

Platform

Keywords

Bioanalytical chemistry • mass spectrometry (LC-MS/MS, LC-QTOF, LC-IMS, LC-PREP) • method development and validation • quantitative and qualitative analyses • biological and environmental matrices • ultra-trace quantification • sample extraction and preparation (SPE, LLE, PPT) • endogenous and exogenous compounds • omics approaches (metabolomics, lipidomics) • organic contaminants (pesticides, pharmaceuticals, PFAS) • biotechnologies • in vivo / in vitro studies • pharmacology and physiology (ADME, PK) • molecular stability • translational research • analytical quality control (QA/QC) • academic and industrial collaborations.

Area of expertise

The platform provides recognized expertise in bioanalytical chemistry and mass spectrometry, dedicated to developing robust analytical tools for the detection and characterization of compounds in biological and environmental matrices :

– Development and validation of LC-MS/MS methods for targeted and ultra-trace quantification of endogenous and exogenous compounds (biomarkers, xenobiotics, contaminants).
– Advanced structural analysis (MS/MS, QTOF) and interpretation of fragmentation spectra.
– Optimization of sample extraction and preparation (SPE, LLE, PPT) and processing of complex matrices (plasma, tissues, water, soil).
– Chemical, enzymatic, and biological stability studies (plasma, tissues, photostability).
– Pharmacokinetic analyses and ADME profiling.
– Targeted omics approaches, including metabolic and lipidomic profiling.
– Analytical integration into in vivo and in vitro studies in pharmacology, toxicology, and physiology.
– Scientific support, including training, experimental design, manuscript assistance, and academic/industrial collaboration.

Services offered

The Bioanalysis Platform provides integrated expertise in analytical chemistry, biology, pharmacology, biotechnology, and environmental sciences. We develop advanced analytical tools for the characterization and quantification of compounds in biological, environmental, cellular, and in vivo / in vitro matrices.

– Development and validation of LC-MS/MS methods for biological, environmental, and cellular matrices.
– Sample preparation and extraction (SPE, LLE, PPT) and purification of ultra-trace compounds.
– Quantification of endogenous and exogenous molecules: biomarkers, metabolites, contaminants, xenobiotics.
– Advanced structural analysis: MS/MS, LC-QTOF, targeted or exploratory fragmentation.
– Biology, Pharmacology & Experimental Studies
– In vitro and in cellulo analyses: enzymatic stability, ligand–receptor interactions, biodegradation, kinetic studies.
– In vivo analyses in partnership with animal research platforms (ADME, bioavailability, PK curves).
– Biological and physico-chemical stability studies (plasma, tissues, photostability, enzymatic assays).
– Targeted omics approaches: metabolomics and lipidomics.
– Analysis of cell cultures, conditioned media, and bioprocess samples.
– Quantification of emerging organic contaminants in water, soils, plants, and animal tissues.
– Analytical support for projects in toxicology, ecotoxicology, bioremediation, and exposomics.
– Analytical and methodological training.
– Support in experimental design (in vitro, in vivo, cellular, environmental).
– Assistance with scientific writing and critical review of analytical results.
– Collaboration with academic, hospital, public, industrial, and biotechnology partners.
– Access to advanced analytical equipment: LC-MS/MS, LC-QTOF, LC-UV, LC-FLD, LC-PREP, LC-IMS, and more.

Responsable

Lounès Haroune
lounes.haroune@usherbrooke.ca
821) 820-8000
https://www.usherbrooke.ca/ips/plateformes-technologiques/bioanalyse

Address

CAMPUS DE LA SANTÉ
3001, 12th Avenue Nord,
Sherbrooke (Québec)
J1H 5N4
CANADA