Centre de Pharmacogénomique Beaulieu-Saucier à l’Institut de Cardiologie de Montréal

Name of entity

Beaulieu-Saucier Pharmacogenomic Centre at the Montreal Heart Institute

Entity type

Platform

Keywords

CAP/CLIA-accredited laboratory, DNA extraction, biobank, genotyping, sequencing, proteomics (Olink), bioinformatics and statistics.

Area of expertise

Expertise in DNA extraction, genomics, biostatistics, bioinformatics, biobanking, and clinical studies

Services offered

1. Clinical Project Management
– Development of clinical specimen collection protocols (Blood, Buccal Swab, Saliva, Plasma, Serum, Tasso)
– Assisting clinical teams with specimen collection logistics

2. DNA and RNA Extraction
-Automated DNA extraction using QIAsymphony and FlexStarPlus platforms
– DNA extraction from whole blood, buccal swab, saliva, and Tasso devices
– RNA extraction from PAXgene RNA tubes

3. Biobanking
– Storage of clinical specimens (DNA, RNA, Plasma, Serum) at -20°C / -80°C in a validated and controlled environment

4. Genotyping
– Genome-wide genotyping using Illumina Infinium technology
– Pharmacogenetic analysis (e.g., CYP2D6 and others)
– Polygenic Risk Score (PRS) analysis
– Targeted genetic panel analysis using iPLEX MassARRAY technology

5. Sequencing
– Targeted sequencing of CHIP-related genes (3000X CleanPlex-UMI)
– Whole genome sequencing at 30–50x and low-pass 2–4x coverage (Illumina DNA PCR-Free / NovaSeq X)

6. Bioinformatics / Genetic Statistics
– Genetic analyses (GWAS, PRS, sequencing)
– Proteomic analyses using Olink platform
– Data analysis from large-scale clinical databases (ICM Biobank, UK Biobank, All of Us, CLSA-ELCV, CARTaGENE)
– Research database and questionnaire development using REDCap

Responsable

Ian Mongrain
ian.mongrain@pharmacogenomics.ca
(514) 770-3667
http://pharmacogenomics.ca

Address

Beaulieu-Saucier Université de Montréal Pharmacogenomics Centre
5000 East Belanger Street
Montreal, Quebec H1T 1C8