News
Impact of Uremia on Regulatory T Cells Proliferation and Phenotype
17 April 2023
Science Pearls
Impact of Uremia on Regulatory T Cells Proliferation and PhenotypeContent of the article :Chronic kidney disease (CKD) patients have a dysfunctional immune system that is chronically and non-specifically activated, leading to low grade inflammation. Inflammation is now considered both a risk factor and a consequence of reduced kidney function and is highly associated with cardiovascular disease (1), which is the leading cause of mortality on dialysis.Regulatory T cells (Tregs) are important inhibitors of proinflammatory responses (2). While Tregs numbers are decreased in patients with CKD, their state and effectiveness remain poorly understood (3).In our study we are investigating the impact of uremia on those cells. Preliminary in vitro and in vivo findings suggest a hypoactive and low-proliferative state in Tregs in uremic milieu.
Nom du congrès/du journal : Kidney Week 2022 by ASNDate du congrès/de parution : 11/06/2022Lieu du congrès/Affiliation de l’auteur : Orange County Convention Center, Orlando, FLNom du présentateur/de l’auteur : Nicolas Valentini
